UKZN and HHMI joined forces to build a state-of-the-art research facility at the epicentre of the TB and HIV epidemics. The KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH) was erected in a prime location on the Nelson R. Mandela School of Medicine campus in Durban, near other major research centres and local hospitals. This eight-story tower was designed for up to nine large scientific research groups working in both standard laboratories and specialised spaces which allow scientists to safely handle dangerous pathogens. These spaces include small labs adjacent to each scientist’s research area and the entire 7th floor. Part of the building is also dedicated to specialised labs that include equipment and space to work in K-RITH’s core research areas: microbiology, immunology, pharmacology, high-throughput biology, and clinical protocol development. A large glass atrium acts as a hub for the campus and physically connects K-RITH with the rest of the University. Inside the K-RITH building, meeting spaces are available that can host large events and accommodate small conferences. The Centre for the AIDS Programme of Research in South Africa (CAPRISA) and the South African biotechnology organisation LifeLab also have office space in the building.